Inside Dr. Peter Attia’s Drug and Supplement Regimen for Health Optimization
Healthy’s Summary
If you’ve ever found yourself Googling Dr. Peter Attia’s supplements in hopes of copying his routine—you’re not alone. He’s one of the most talked-about figures in the longevity and health optimization world. But here’s the thing: Attia’s supplement stack isn’t about quick fixes or generic protocols. It’s about personalization, backed by bloodwork, genetics, and a deep understanding of his own body.
Before he adds a single capsule, Dr. Attia focuses on nutrition, movement, sleep, and recovery. Supplements come after the foundations are dialed in—not before.
That said, his regimen includes tools for cellular aging, cardiovascular health, brain function, hormone optimization, and better sleep. Some of these are prescription medications. Others are well-known vitamins or compounds with emerging research behind them. But the bigger takeaway? It’s the why behind each choice—and the fact that everything is reassessed regularly.
Whether you’re curious about NAD+ boosters or wondering if magnesium threonate is worth it, here’s a closer look at how Dr. Peter Attia’s supplements fit into his overall strategy—and what that might mean for you.
How does Dr. Peter Attia choose his supplements?
There’s no guesswork in Dr. Peter Attia’s supplements plan. Instead of following trends, he takes a precision medicine approach. That means constant testing, thoughtful analysis, and regular adjustments based on what’s going on inside his body.
He uses his supplement regimen to support specific systems: metabolic health, mitochondrial function, inflammation, cognition, and more. But there’s no blanket protocol. If a nutrient isn’t needed? He leaves it out.
Another key piece: supplements never come first. Attia has said again and again that lifestyle is the foundation. Sleep, whole foods, physical training—those earn the right to add on the “extras.” His belief? If your basics aren’t solid, no supplement is going to save you.
This is a mindset shift. Instead of asking, “What does he take that I should copy?” try: “What am I missing—and how can I find out?”
What’s actually in Dr. Peter Attia’s supplements routine?
Let’s get specific. While Attia is constantly refining his routine, here’s a snapshot of what’s publicly known about the types of supplements and medications he uses, and why.
1. For Longevity & Cellular Function
- Rapamycin: Taken intermittently to suppress mTOR and promote autophagy (the body’s internal clean-up system). Believed to slow age-related cellular damage.
- Metformin or Berberine: Both help regulate blood sugar and improve insulin sensitivity. Metformin is prescription-only and more widely studied.
- NAD+ Precursors (NR or NMN): Support mitochondrial energy and DNA repair—though human data is still evolving.
2. For Cardiovascular & Metabolic Health
- Omega-3s (EPA/DHA): High-dose fish oil to reduce systemic inflammation and protect heart function.
- ApoB-lowering meds (e.g. statins, PCSK9 inhibitors): Used if lipid panels suggest high cardiovascular risk.
- Magnesium (RBC tested): Plays a role in vascular tone, muscle relaxation, and sleep—yet often overlooked in standard labs.
3. For Brain Performance
- Magnesium Threonate: A form of magnesium that crosses the blood-brain barrier—may aid memory and cognitive clarity.
- Creatine Monohydrate: Traditionally known for athletic performance, but it’s also a brain energy booster.
- Lion’s Mane Mushroom: A natural nootropic believed to support nerve growth and brain plasticity (though data is limited).
4. For Hormonal Optimization
- Testosterone Therapy (when indicated): Helps preserve lean muscle, energy, and mental sharpness with age.
- DHEA: Supports adrenal health and hormonal balance—especially when levels naturally decline over time.
5. For Sleep & Recovery
- Melatonin (low dose): Not used nightly, but as a tool to reset circadian rhythm when needed.
- Glycine & Magnesium Glycinate: Help promote relaxation and support more restorative sleep cycles.
- Apigenin: A plant compound with gentle calming effects—may reduce stress and help with sleep onset.
Ask Healthy
Should you copy Dr. Peter Attia’s supplement routine?
Short answer? Not blindly.
Dr. Peter Attia’s supplements are informed by his personal lab data. He tracks his glucose, cholesterol particles, inflammatory markers, and more—often with tools most people don’t have at home.
That doesn’t mean you can’t benefit from some of the same supplements. But what works for Attia might be overkill—or ineffective—for someone else. For example, metformin is powerful, but it can blunt exercise benefits in some people. Omega-3s are great, but only if your ratio of fatty acids actually needs adjusting.
And that’s the core of his philosophy: Test, don’t guess. Your body is the best lab you’ve got. If you want to build a supplement routine that truly supports your healthspan, it starts with learning your baseline and building up from there—just like he does.
The Takeaway
Dr. Peter Attia’s supplements routine is impressive—but the real lesson is how he builds it: slowly, intentionally, and always in conversation with his data. He’s not chasing trends. He’s creating a system that supports his health long-term—and adapting it as new information comes in.
If you’re curious whether NAD+ boosters, magnesium threonate, or melatonin belong in your own stack, don’t start with a bottle. Start with your habits. Then your labs. Then—maybe—your supplements.
Want to dig deeper?
AgeProof: Optimize Health Today for a Longer, Stronger Tomorrow
Longevity optimization is a personalized journey focused on empowering you to build habits and adopt practices that promote a long, healthy, and fulfilling life. Engaging conversations provide science-backed insights, tools, and actionable guidance to help optimize physical health, mental resilience, and lifestyle habits that are proven to support longevity. You can explore topics like nutrition, exercise, cognitive health, sleep optimization, and stress management.
Enroll in one of Healthy’s Programs to log, track and learn more about your Health, one conversation at a time.
Start Program
